Models by two researchers suggest that the SARS-CoV-2 coronavirus attack haemoglobin. And it disrupts the transport of oxygen by red blood cells. However, their study suffers from a lack of evidence. So far their conclusions cannot be justified by the results provided. We have already learnt how we can prevent coronavirus COVID-19 from spreading. We have also learned the nature of the treatment of COVID-19 in different countries. However, at least from our discussion, something will be clear today. The claim that the SARS-Cov-2 Coronavirus attack haemoglobin is based without proper evidence and proper result!
Without wasting a single time, let’s start our discussion.
At the beginning of April 2020, Wenzhong Liu and Hualan Li, two Chinese researchers from the Universities of Sichuan and Yibin, put online the preliminary results of a modelling study on the proteins of the SARS-CoV-2 coronavirus.
This study suggests that in silico, i.e. according to calculations and computer simulations, certain proteins of the virus could have an action on haemoglobin – a molecular complex contained in red blood cells, composed in particular of four haem molecules and enabling oxygen to be transported in the body.
Is It A Blood Disease? Not Pneumonia?
According to these researchers, the sars-cov2 coronavirus is not pneumonia. It is a blood disease. Specifically, these coronavirus proteins could bind to or even attack the haemoglobin haeme. This can take place in such a way as to dissociate its two main components: an iron atom and a molecule called porphyrin. Thus, the SARS-CoV-2 would prevent red blood cells from efficiently taking up oxygen in the lungs and distributing it to the tissues: COVID-19 would not be pneumonia but a blood disease!
These findings are then widely shared on social networks such as Twitter, on news blogs such as the one associated with the Strasbourg university hospitals, and even by learned societies, such as the French Society of Nurse Anaesthetists. Everywhere the news spread. The news says that Coronavirus attacks haemoglobin.
However, a few days after the publication of this preliminary study without prior rereading by other specialists on the ChemRxiv server, a few criticisms of the work of the two authors emerge. For example, on the same server, a professor of crystallography at the University of Cambridge published a brief commentary. The commentary was according to which the modelling carried out not only suffered from a lack of rigour and errors in the interpretation of the results but was also not supported by any clinical or biological observations. The observation should carry out on patients with COVID-19. Is this a serious scientific study or a fine work of science fiction?
Coronavirus Attacks Haemoglobin: Errors Modeling Work
In their study, Wenzhong Liu and Hualan Li reported using a three-step process. While the approach adopted, which is relatively classic, seems to be correct overall. However, the implementation of each of these three steps suffers from a lack of rigour, or even flagrant errors in interpreting the results. Professor Catherine Etchebest, a specialist in molecular modelling who works as part of a research team attached to the National Institute of Blood Transfusion, said that the research has errors in modeling work
A British Medical professional also affirmed that Wenzhong Liu and Hualan Li report using a three-step process is lack of evidence or even flagrant errors are there. He indeed challenged the study of these Chinese researchers in Flawed methods in “COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism”
The media should release news justifying the facts. Otherwise, many will accept the claim that Coronavirus attacks haemoglobin. The scientific study should be serious. It should not be a fiction! COVID-19 becomes a blood disease, not pneumonia! However, the World Health Organization (WHO) has already declared that COVID-19 is pneumonia.